Oncological outcomes in patients undergoing radical cystectomy at a tertiary care center in Bogotá, Colombia: experience over the last 6 years

Oncological outcomes in patients undergoing radical cystectomy at a tertiary care center in Bogotá, Colombia: experience over the last 6 years

Daniel A.Urbina 1 , Luis M. Becerra 2 , Alejandro Lora 3 , Diana L. Garzón 4 , David A. Cortés 1 , Iván Ortiz 1 , Sthepani Gómez 4, Laura S. Jurado 5, Michelle A. Bejarano 5, Sofía Muñoz-Medina 6

1 Servicio de Urología, Facultad de Medicina, Fundación Universitaria Sanitas, Bogotá, Colombia; 2 Servicio de Urología Oncológica, Clínica Universitaria Colombia, Bogotá, Colombia; 3 Servicio de Cirugía General, Grupo Pared Abdominal, Clínicas Colsanitas, Fundación Universitaria Sanitas, Bogotá, Colombia; 4 Grupo de Investigación en Urología, Clínica Universitaria Colombia, Bogotá, Colombia; 5 Facultad de Medicina, Fundación Universitaria Sanitas, Bogotá, Colombia; 6 Oficina de Investigación, Fundación Universitaria Sanitas, Bogotá, Colombia

*Correspondence: Diana L. Garzón. Email: lore.garzon9211@gmail.com

Abstract

Objective: Determine oncological outcomes in patients with muscle-invasive bladder cancer undergoing radical cystectomy. Method: This is a descriptive, observational study of patients from a university hospital in Bogotá, Colombia, between 2016 and 2022, with a follow-up period of ≥ 6 months. A descriptive analysis was performed, and survival was represented in Kaplan-Meier curves. Results: Forty-two patients were included. The mean age was 64.64 years (SD: 9.58), mainly comprising men (80.95%), and the most common histological subtype was high-grade urothelial carcinoma in 71.43%. The most performed urinary diversion was cutaneous ureterostomy in 50% of cases. Incidence of bladder cancer recurrence was found in 28%, tumor-related mortality was 38,09%, and non-tumor-related mortality was 26,19%, for a global mortality of 64.29% (95% CI: 48.03-78.45). Conclusions: We found a slightly lower cumulative incidence of relapse compared to the general population. However, the five-year global mortality of 64% is above what is documented in the literature, and the use of cutaneous ureterostomy as the urinary diversion was comparatively higher than in the rest of the studies.

Keywords: Urinary bladder neoplasms. Cystectomy. Urinary diversion.

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