Estradiol/testosterone ratio: unveiling links between hormones, sexual function, and health in chronic non-communicable diseases
Introduction Estrogens and androgens are steroid hormones present in both men and women, regulated by the hypothalamic-pituitary-gonadal (HPG) axis. The secretion of gonadotropin-releasing hormone (GnRH) by the hypothalamus stimulates the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the anterior pituitary gland, which ultimately leads to the production of testosterone (T). Testosterone acts […]
Concordance of diagnostic tests, ultrasound of urinary tract versus non-contrast CT in urolithiasis in a four-level center in Bogotá, Colombia
Introduction In the approach and diagnosis of ureteral stone, tomography with a focus on the urinary tract is the gold standard1. However, urinary tract ultrasound (USut) may become more accessible, fast, and cost-effective in emergency settings. Ultrasound has the above advantages, as well as the absence of exposure to ionizing radiation2. USut has been considered […]
Treatment patterns in hormone-sensitive metastatic prostate cancer: data from a referral hospital in Bogota, real-world evidence study
Introduction Treatment for hormone-sensitive metastatic prostate cancer (mHSPC) has evolved in recent years with the addition of multiple treatment intensification options associated with androgen deprivation therapies (ADT), which were previously considered the mainstay of treatment, Treatment intensification includes taxane-containing chemotherapy and therapies that target the androgen receptor axis-directed therapies (ARATs)1. During the past 7 years, […]
Health-care distribution of patients with genitourinary birth defects in Colombia: a spatial analysis of registered cases
Introduction Genitourinary birth defects are reported to be present in approximately 10-30% of all newborns and can lead to varying degrees of morbimortality1,2. Congenital kidney anomalies are responsible for up to 50% of chronic renal failure in children worldwide2. A cohort study conducted by Calderon-Margalit et al.3 found a hazard ratio of 4.19 (95% confidence […]
Answer: Oncological outcomes in non-seminomatous testicular tumors and residual mass after cisplatin-based chemotherapy
The study “Oncological outcomes in non-seminomatous testicular tumors and residual mass after cisplatin-based chemotherapy” by Ocampo-Gómez et al., aims to describe the oncological outcomes of patients with clinical stages II and III non-seminomatous germ cell tumors (NSGCT) that developed residual masses (RMs) post-quimiotherapy and were treated with either retroperitoneal lymph node dissection (RPLND) or observation1. […]
Bleeding and thrombotic risk after direct oral anticoagulant interruption for urological surgery
Introduction Direct oral anticoagulants (DOACs) have been in use for nearly 15 years and have become the most prescribed oral anticoagulants (74% DOACs in the UK in 2019)1. DOAC use has gained popularity over warfarin mainly due to more favorable and predictable pharmacokinetics. There is no need for International Normalization Ratio blood test monitoring, and […]
Disease burden and treatment choice for metastatic hormone-sensitive prostate cancer in Colombia
Introduction Prostate cancer (PCa) is a highly prevalent disease worldwide, with more than 1.4 million new cases each year1. According to GLOBOCAN, in 2020, there were 14,460 new cases of PCa in Colombia, with an age-standardized incidence rate of 49.8/100,000 men1. In relation to its high prevalence, PCa is a public health priority in national […]
piRNAs and PIWI-like proteins in cancer and their future as biomarkers and therapeutic targets in prostate cancer: a systematic review
Introduction Prostate cancer (PCa) is the eighth leading cause of death among older men worldwide. According to the 2022 GLOBOCAN report, this malignancy accounted for 397,430 deaths globally, with 61,957 occurring in Latin America and the Caribbean1,2. In addition, PCa is highly metastatic, has a low cure rate, and exhibits significant resistance to treatment. These […]
Climacturia after prostatectomy: hidden struggles in sexual well-being
Introduction Radical prostatectomy stands as the primary curative intervention for localized prostate cancer1. Nevertheless, this procedure is accompanied by potential risks in terms of urinary continence and sexual health. Studies have reported urinary incontinence in 42% of patients 24 months after surgery1. On the other hand, in sexual health, the most well-known adverse outcome is […]
Association between sociodemographic characteristics and late diagnosis of prostate cancer: an observational study in three Colombian departments
Introduction Prostate cancer represents one of the main causes of malignancy in the world and the leading cause of cancer in men1. Epidemiologically, a figure of 1,467,000 cases/year was reported for 2023, representing 7.34% of the total number of cancer cases reported, ranking it as the fourth most frequent type of cancer, surpassed by mama, […]
