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*Correspondence: Jesús Sánchez-Lozano. Email: jesus-dbz@hotmail.com
Erectile dysfunction is the inability to maintain a penile erection. It is estimated that there are 152 million men with erectile dysfunction in the world, and this number is expected to increase to 322 million in the year 2025. The objective is to carry out a review on the efficacy of low-intensity pulsed ultrasound in patients with erectile dysfunction. A review was carried out following the PRISMA regulations. The PubMed, Cinahl, PsycINFO, SPORTDiscus, Academic Search Complete, Lilacs, IBECS, CENTRAL, SciELO, and WOS databases were consulted. The Cochrane tool was used to assess the risk of bias and the quality of the evidence was assessed with the GRADE system. Low intensity pulsed ultrasound is effective and safe for erectile dysfunction. The application frequency ranged from two to three times per week, and the total number of sessions ranged from eight to 21. All the studies showed safety and no major adverse effects occurred. Low intensity pulsed ultrasound is effective; it promotes nerve regeneration and improves erectile function by enhancing Schwann cell proliferation and migration, and expression of nerve growth factor.
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