Laparoscopic radical nephrectomy of left renal tumor with demonstration of Rosai-Dorfman disease: case report

Laparoscopic radical nephrectomy of left renal tumor with demonstration of Rosai-Dorfman disease: case report

Laura S. Trujillo-Panche 1 , Daniel F. Reyes-Vega 2 , Óscar F. Cortés-Otero 3, Carolina Silva-Morera 4 , Mario A. Caviedes-Cleves 5

1 Servicio de Hospitalización, Clínica Mediláser, Neiva, Colombia; 2 Facultad de Medicina, Universidad Surcolombiana, Neiva, Colombia; 3 Servicio de Urología, Clínica Mediláser, Neiva, Colombia; 4 Departamento de Patología, Clínica Mediláser, Neiva, Colombia; 5 Departamento de Patología, Universidad de Antioquia, Medellín, Colombia

*Correspondence: Laura S. Trujillo-Panche. Email: sofiatrupanche@gmail.com

Abstract

Rosai-Dorfman’s disease is defined as a histiocytosis with a generally benign course, characterized by the accumulation of lymph nodes of histiocytes that present emperipolesis, and immunohistochemical positivity for S-100, and CD68, and negativity for CD1a and langerin. Its exact etiology is unknown, being associated with autoimmune, infectious, and genetic factors. Renal involvement is rare, being identified in less than 5% of patients. We present the case of a 54-year-old man, with incidental discovery of a tumor lesion that compromised the lower pole of the left kidney, who underwent radical nephrectomy and whose histopathological findings confirmed Rosai-Dorfman’s disease.

Keywords: Nephrectomy; Laparoscopic; Emperipolesis; Histiocytosis; Kidney

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